Professor Byrnes is leading tax authority with nine Lexis treatises and compendia, and co-author with Robert Bloink of Tax Facts books. His nine Lexis titles are: Tax of Oil & Gas Transactions; LexisNexis Guide to FATCA & CRS Compliance; Practical Guide to U.S. Transfer Pricing; Money Laundering, Asset Forfeiture and Recovery, and Compliance--A Global Guide; Taxation of Intellectual Property and Technology; Foreign Tax and Trade Briefs; Tax Havens of the World; Texas Estate Planning; and International Withholding Tax Treaty Guide.

In 1994 William Byrnes pioneered online legal education, in 1998 created the first online LL.M. acquiesced by the ABA, and is now offering the 5th edition of his wealth and risk management graduate program online via Texas A&M.