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Prior posts have discussed various animal studies that have reported the potential for adverse impacts from BPA exposure, as well as the controversial conclusions of FDA under President Bush in assessing the risk of such exposure to humans.
Recently published research suggests that the standard approach used in animal model studies for assessing exposure to BPA may underestimate that exposure. Researchers compared BPA concentrations in mice that were given a steady diet supplemented with BPA throughout the day, compared to the more common lab method of single exposure, and found an increased absorption and accumulation of BPA in the blood of mice. The authors note that this approach is a better method to mirror the chronic and continuous exposure to BPA that occurs in animals and humans. The result of this exposure scenario is that there is a significantly greater increase in the active form of BPA (unconjugated BPA-d6) which can bind to sex steroid receptors and exert adverse effects.
The study can be found at http://ehp03.niehs.nih.gov/article/info:doi%2F10.1289%2Fehp.1003385.