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It seems like it would be seamless. Employers reimburse employees for reimbursable business expenses, like business travel and lodging, and employees receive the nontaxable reimbursement. But this area of tax law is riddled with potholes that can (technically speaking) cause advances and reimbursements to be treated as taxable wage income. Be sure you comply with the accountable plan rules of Treas. Reg. § 1.62-2.
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