Tags: overdoses , opioid , OxyContin , placebo , codeine , addiction , prescription drug monitoring program , endocrinological harms , long-term opioid therapy , opioid abuse , nonopioid therapy , Chronic pain , dose initiation , quality of life , motor vehicle accidents , Vicodin , risk mitigation strategies , urine drug screening , dose titration , dose escalation , fractures , cardiovascular events , patient education , falls